A U.S. scientist assigned to a CIA-run, covert, overseas assignment goes missing. Meanwhile, while in Manhattan to ring the NY Stock Exchange bell, Cris De Niro is asked by the scientist's father, a childhood friend of his, to investigate. De Niro and The Watchman Agency soon uncover a secret Iranian-Russian alliance with deadly intentions.

As Iranian bio-terrorism and Russian espionage reach into the White House, the spectre of Iran as a nuclear power looms. World War III could break out in the Middle East unless De Niro & Company can Rise to the Call