Ginger and her fellow Domino Girls pool their funds to buy an old Colonial-style home on the outskirts of town and convert it into a bed and breakfast. The house is rumored to be haunted - which enables them to get the place at a bargain. They name it "Ginger Bread House" banking on Ginger's notoriety as a famous cake baker to bring in the guests. She will provide a daily supply of her freshly-baked cakes to sweeten their stay.

But on the very first night, guests begin to see and hear strange things. Ginger manages to settle them down - until one of the guests is found dead. News quickly spreads, and gossipers rename the new bed & breakfast, "Ginger DEAD House". Now every phone call is another cancellation.

The Domino Girls see their life savings about to go down the drain. So, Ginger proposes that the four of them work together to solve the mystery of the ghosts and the murder. "Domino Sleuth Club" is born.

But their task may prove more difficult and dangerous than anyone could have imagined.